Guide for Aviation Medical Examiners

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Pharmaceuticals (Therapeutic Medications)
Acne Medications

1. Code of Federal Regulations:
• First-Class Airman Medical Certificate: 67.113(c)
• Second-Class Airman Medical Certificate: 67.213(c)
• Third-Class Airman Medical Certificate: 67.313(c)


2. Medical History:
   For applicants using isotretinoin (Accutane), there is a mandatory 2-week waiting period after starting isotretinoin prior to consideration. This medication can be associated with vision and psychiatric side effects of aeromedical concern - specifically decreased night vision/ night blindness and depression. These side-effects can occur even after cessation of isotretinoin. A report must be provided with detailed, specific comment on presence or absence of psychiatric and vision side-effects. The AME must document these findings in Block 60, Comments on History and Findings. Some applicants will have to be deferred. For applicants issued, there must be a NOT VALID FOR NIGHT FLYING restriction on the medical certificate. A waiting period and detailed information is required to remove this restriction. The restriction cannot be removed until all the requirements are met. See Pharmaceutical Considerations below.


3. Aeromedical Decision Considerations:
   See Item 40, Skin.


4. Protocol: N/A


5. Pharmaceutical Considerations:
• Use of isotretinoin must be permanently discontinued for at least 2 weeks prior to consideration date (confirmed by the prescribing physician) and;
• Eye evaluation must be done in accordance with specifications in 8500-7 and;
• The airman must provide a signed statement of discontinuation that:
• Confirms the absence of any visual disturbances and psychiatric symptoms, and
• Acknowledges requirement to notify the FAA and obtain clearance prior to performing any aviation safety-related duties if use of isotretinoin is resumed