The Drug Abatement Division (AAM-800) is the principal agency element responsible for the development, implementation, administration, and compliance monitoring of the aviation industry drug and alcohol testing programs as set forth in the Department of Transportation (DOT) and Federal Aviation Administration (FAA) regulations, 49 CFR part 40 and 14 CFR part 120. The regulations require all part 119 certificate holders authorized to operate under parts 121 and 135, air tour operators (as defined in § 91.147) and air traffic control facilities not operated by FAA or under contract to the U.S. Military to implement drug and alcohol testing programs.

The Program Administration Branch (AAM-810) is also located at FAA headquarters in Washington, D.C., and has oversight of inspection scheduling activities associated with all regulated employers, manages the program registration process and all Management Information System (MIS) reports. It assists with administrative and program functions associated with budget, logistics, training, and maintenance of the Division's Compliance and Enforcement Tracking Subsystem. It has responsibility for the program's credentialing program. It is also responsible for the Voluntary Disclosure Reporting Program established in FAA Advisory Circular AC 00-58B. It also reviews legal enforcement actions that are taken as a result of employer program inspections.

The Program Policy Branch (AAM-820) is also located at FAA headquarters in Washington, D.C., and has the primary responsibility for development of all program and enforcement policy, and rulemaking activities in cooperation with other elements of the division. In addition it provides technical advice to the agency and aviation industry on drug and alcohol testing regulations. It serves as the focal point for Freedom of Information Act (FOIA) requests and Congressional inquiries.

The Special Investigations Branch (AAM-830) is also located at FAA headquarters in Washington, D.C., and has the primary responsibility for investigating all complaints associated with rule violations or allegations. It conducts all investigations concerning individual or employee-related violations, e.g., refusals to submit to testing, positive drug test results, alcohol violations, and return-to-duty violations.

The Compliance and Enforcement Centers are located in Miramar, FL (AAM-860), Dallas-Ft. Worth, TX (AAM-840), and Los Angeles, CA (AAM-850). The Centers have the responsibility of oversight for all field inspection activities.