FAA Office of Aerospace Medicine
Civil Aerospace Medical Institute

Report No: DOT/FAA/AM-63/22

Title and Subtitle: The mechanisms of intrarenal hemodynamic changes following acute arterial occlusion

Report Date: October 1963

Authors: Hinshaw LB, Page BB, Brake CM, Emerson TE, Masucci FD

Abstract: The hemodynamic response of the kidney to acute arterial occlusion is poorly understood. The purpose of the present study was to determine intrarenal hemodynamic changes in intact and isolated kidneys following arterial occlusion.

The relative roles of metabolic, myogenic and tissue pressure influences on the post-occlusion response were evaluated. The [illegible] of the kidney to occlusion was found to be complex depending on the interaction of a variety of physical and humoral forces. Increases in renal resistance appeared to be due in part to adrenergic agents and were enhanced by extending time of occlusion and lowering the arterial pressure.

The combined effects of pre-venous dilation and [illegible] tissue pressure resulted in a decreased resistance following shorter periods of occlusion. Pre-venous dilation was accounted for by depressed vascular sensitivity to [illegible] agents and the presence of vasodilator substances. Changes in venous [illegible] resistance were found to be of primary importance in both the autoregulatory phenomenon and the post=occlusion hyperemic response to short (fifteen second) occlusion periods.

Key Words: reactive hyperemia, renal ischemia, renal hypoxia, renal arterial occlusion, the kidney and vascular resistance, renal stress.

No. of Pages: 31