FAA Office of Aerospace Medicine
Civil Aerospace Medical Institute

Report No: DOT/FAA/AM-63/26

Title and Subtitle: Acute and chronic effects of the insecticide endrin on renal function and renal hemodynamics

Report Date: October 1963

Authors: Reins DA, Holmes DD, Hinshaw LB

Abstract: Chronic and acute effects of the insecticide endrin on renal function were studied in dogs. Animals were exposed to endrin chronically by intramuscular injection and acutely by intravenous infusion. In acute studies dogs developed systemic hypertension and increased renal vascular resistance attributable to a sympatho-adrenal action.

Basic renal autoregulation was not impaired by endrin but was masked by effects of blood borne adrenergic agents. Changes in renal function were minimal. In chronic studies dogs developed progressive systemic hypotension with variable changes in renal function and terminal renal vasodilation in some instances. Pathological findings were minimal and could be related to hemodynamic alteration in the peripheral vasculature.

Results from this investigation provide no evidence for renal failure due to chronic insecticide poisoning.

Key Words: insecticides, poisons, kidney, renal function, insecticides and the kidney.

No. of Pages: 12