Office of Aerospace Medicine Technical Reports
FAA Office of Aerospace Medicine
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-85/4
Title and Subtitle: Inhalation toxicology: IV. Times to incapacitation and death for rats exposed continuously to atmospheric hydrogen chloride gas.
Report Date: May 1985
Authors: Crane CR, Sanders DC, Endecott BR, Abbott JK.
Abstract: Laboratory rats were exposed continuously to measured atmospheric concentrations of hydrogen chloride (HC1) gas until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel. These two endpoints, time- to-incapacitation and time-to-death, were equated to atmospheric HC1 concentration by statistically derived regression equations.
The possible relationship between the effective toxic doses of HC1 gas for rats and those reported for humans is discussed. Originator supplied keywords include: Combustion toxicology; Smoke, Irritant gas; Time-to-incapacitation; Time-to- death; Aircraft cabin fire.
Key Words: toxicology, inhalation, hydrogen chloride, exposure (general), rats, humans, gases, time, regression analysis, combustion, smoke, lethality, losses, equations, death, aircraft fires, lethal dosage, laboratory animals, aircraft cabins, irritating agents.
No. of Pages: 22
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-85/4
Title and Subtitle: Inhalation toxicology: IV. Times to incapacitation and death for rats exposed continuously to atmospheric hydrogen chloride gas.
Report Date: May 1985
Authors: Crane CR, Sanders DC, Endecott BR, Abbott JK.
Abstract: Laboratory rats were exposed continuously to measured atmospheric concentrations of hydrogen chloride (HC1) gas until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel. These two endpoints, time- to-incapacitation and time-to-death, were equated to atmospheric HC1 concentration by statistically derived regression equations.
The possible relationship between the effective toxic doses of HC1 gas for rats and those reported for humans is discussed. Originator supplied keywords include: Combustion toxicology; Smoke, Irritant gas; Time-to-incapacitation; Time-to- death; Aircraft cabin fire.
Key Words: toxicology, inhalation, hydrogen chloride, exposure (general), rats, humans, gases, time, regression analysis, combustion, smoke, lethality, losses, equations, death, aircraft fires, lethal dosage, laboratory animals, aircraft cabins, irritating agents.
No. of Pages: 22
Last updated: Friday, June 1, 2012