Aerospace Medicine Technical Reports
FAA Office of Aerospace Medicine
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-05/8
Title and Subtitle: Enantiomeric Analysis of Ephedrines and Norephedrines
Report Date: April 2005
Authors: Wang SM, Lewis RJ, Canfield D, Lia TL, Liu RH
Abstract: Concerned with variations in abuse potential and control status among various isomers of ephedrines and norephedrines, this study was conducted to develop an effective method for the simultaneous analysis of eight ephedrine-related compounds along with structurally similar cathinones.
Among various approaches studied, a 60m HP-5MS (0.25 mm ID, 0.25 �m film thickness) was successfully used to characterize the following compounds that were derivatized with (�)-a-methoxy-a-trifloromethylphenylacetic acid (MTPA): (+)-cathinone, (�)-cathinone, (+)-norephedrine, (�)-norephedrine, (+)-norpseudoephedrine, (+)-ephedrine, (�)-ephedrine, (�)-pseudoephedrine, (+)-pseudoephedrine. (�)-Cathine standard was not available but should also be resolvable under this analytical procedure. This method was successfully applied to the analysis of selected cold remedies for characterizing the enantiomeric compositions of the compounds present in these samples.
Key Words: Enantiomer, Ephedrine, Norephedrine, Chiral Derivatization
No. of Pages: 14
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-05/8
Title and Subtitle: Enantiomeric Analysis of Ephedrines and Norephedrines
Report Date: April 2005
Authors: Wang SM, Lewis RJ, Canfield D, Lia TL, Liu RH
Abstract: Concerned with variations in abuse potential and control status among various isomers of ephedrines and norephedrines, this study was conducted to develop an effective method for the simultaneous analysis of eight ephedrine-related compounds along with structurally similar cathinones.
Among various approaches studied, a 60m HP-5MS (0.25 mm ID, 0.25 �m film thickness) was successfully used to characterize the following compounds that were derivatized with (�)-a-methoxy-a-trifloromethylphenylacetic acid (MTPA): (+)-cathinone, (�)-cathinone, (+)-norephedrine, (�)-norephedrine, (+)-norpseudoephedrine, (+)-ephedrine, (�)-ephedrine, (�)-pseudoephedrine, (+)-pseudoephedrine. (�)-Cathine standard was not available but should also be resolvable under this analytical procedure. This method was successfully applied to the analysis of selected cold remedies for characterizing the enantiomeric compositions of the compounds present in these samples.
Key Words: Enantiomer, Ephedrine, Norephedrine, Chiral Derivatization
No. of Pages: 14
Last updated: Friday, June 1, 2012