Aerospace Medicine Technical Reports
FAA Office of Aerospace Medicine
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-63/11
Title and Subtitle: In vivo measurement of gas pressure in mammalian tissue
Report Date: July 1963
Authors: Lategola MT
Abstract: An in vivo method for the quantitative estimation of total gas pressure in mammalian tissue has been established. This method utilizes a rigid-walled capsule specially constructed to be permeable to oxygen, carbon dioxide and nitrogen (O2, Co2, and N2), but negligible permeable to water vapor. The results obtained at equilibrium, after subcutaneous implantation of this capsule, demonstrate directly that the total gas pressure in the adjacent tissue, which is represented by the intracapsular total gas pressure, is about 40 to 50 mmHg less that the concomitant atmospheric pressure.
The difference between these gas pressures is a result of the metabolic gas exchange and may, therefore, be used to detect quantitative changes in tissue gas metabolism. Work is in progress on miniaturization and modification of the capsule device so that it may be used at intravascular as well as tissue sites in a broad variety of physiological states.
Key Words: gas pressure, mammalian, oxygen, carbon dioxide, nitrogen, implantation, capsule
No. of Pages: 9
Civil Aerospace Medical Institute
Report No: DOT/FAA/AM-63/11
Title and Subtitle: In vivo measurement of gas pressure in mammalian tissue
Report Date: July 1963
Authors: Lategola MT
Abstract: An in vivo method for the quantitative estimation of total gas pressure in mammalian tissue has been established. This method utilizes a rigid-walled capsule specially constructed to be permeable to oxygen, carbon dioxide and nitrogen (O2, Co2, and N2), but negligible permeable to water vapor. The results obtained at equilibrium, after subcutaneous implantation of this capsule, demonstrate directly that the total gas pressure in the adjacent tissue, which is represented by the intracapsular total gas pressure, is about 40 to 50 mmHg less that the concomitant atmospheric pressure.
The difference between these gas pressures is a result of the metabolic gas exchange and may, therefore, be used to detect quantitative changes in tissue gas metabolism. Work is in progress on miniaturization and modification of the capsule device so that it may be used at intravascular as well as tissue sites in a broad variety of physiological states.
Key Words: gas pressure, mammalian, oxygen, carbon dioxide, nitrogen, implantation, capsule
No. of Pages: 9
Last updated: Friday, June 1, 2012