- Associate Administrator for Security and Hazardous Materials Safety
- Claudio Manno
- Deputy Associate Administrator for Security and Hazardous Materials Safety
- Tonya Coultas
- Director, Office of National Security Programs & Incident Response
- Jennifer Roberson (Acting)
- Director, Office of Infrastructure Protection
- Patricia Pausch
- Director, Office of Hazardous Materials Safety
- Ben Supko
- Director, Office of Investigations
- Michelle Root
- Director, Office of Business and Mission Services
- Don Faulkner
- Director, Office of Personnel Security
- Gerald Moore